Side effects of anti-inflammatories?
- Thread starter Ruhl
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McFerret85
New Member
This article indicates that taking anti-inflammatory drugs like acetaminophen and ibuprofen suppresses the increased rate of protein synthesis that normally occurs post exercise.
http://www.ncbi.nlm.nih.gov/entrez....bstract
I don't know what effect sleep has on inflammation.
http://www.ncbi.nlm.nih.gov/entrez....bstract
I don't know what effect sleep has on inflammation.
You also have to be aware of the amount of anti-inflammatories, a small dose daily is not going to have much of an effect on protein synthesis, but large doses through out the day will (potentially)
Fish oils also decrease prostaglandin synthesis, so there would be potential for a reduced protein synthesis with chronic high dose fish oil supplementation. (altho their effect is relatively weaker than large dose ibuprofen)
Certain pro inflammatory cytokines are involved in the sleep process, but as a whole body overall inflammation, its likely that a chronic lack of sleep would increase it, as stress does.
Fish oils also decrease prostaglandin synthesis, so there would be potential for a reduced protein synthesis with chronic high dose fish oil supplementation. (altho their effect is relatively weaker than large dose ibuprofen)
Certain pro inflammatory cytokines are involved in the sleep process, but as a whole body overall inflammation, its likely that a chronic lack of sleep would increase it, as stress does.
One more thing that should also be kept in mind about generalizing the results of this study, is that the authors didn't examine timing of the doses in relation to protein synthesis.
An interesting note about inflammation and healing in general (muscle or otherwise) is that if inflammation is initiated, (by damage in this case), before an anti-inflammatory agent is administered, healing is not affected. So, it seems that once the inflammatory "ball" gets rolling, the repair process proceeds in spite of decreased inflammatory mediator production.
These authors administered full and continuous doses of IB and APAP 24 hours before taking protein samples. Thus, cyclooxygenases were inhibited before damage was initiated. The story may have been different had they taken the treatment immediately post-training. However, I am not aware of any studies that looked specifically at this sort of dosing schedule.
The point would be that if you take an NSAID to decrease DOMS, you may want to wait until after training to do so, and then stop treatment perhaps 12 to 24 hours prior to your next session to allow clearance of the drug and/or recycling of your cyclooxygenases.
An interesting note about inflammation and healing in general (muscle or otherwise) is that if inflammation is initiated, (by damage in this case), before an anti-inflammatory agent is administered, healing is not affected. So, it seems that once the inflammatory "ball" gets rolling, the repair process proceeds in spite of decreased inflammatory mediator production.
These authors administered full and continuous doses of IB and APAP 24 hours before taking protein samples. Thus, cyclooxygenases were inhibited before damage was initiated. The story may have been different had they taken the treatment immediately post-training. However, I am not aware of any studies that looked specifically at this sort of dosing schedule.
The point would be that if you take an NSAID to decrease DOMS, you may want to wait until after training to do so, and then stop treatment perhaps 12 to 24 hours prior to your next session to allow clearance of the drug and/or recycling of your cyclooxygenases.
While not showing the complete picture, it is still showing the people treated with A/I before (and more than likely directly after a training session) will have no real increase in protein synthesis at 24hr point, where as those who do not take A/is will still have an increase.[b said:
Whether this difference at 24hrs will be enough to affect overall 24hr protien balance is unknown.
(also, basically no studies seem to measure earlier time points, even Phillips et al 48hr protien synthesis experiemnt measured FSR/FBR at rest, 3hr, 24hr and 48hr. There was not a lot of difference between 3 and 24hr time periods (not significant anyway)
Actually, this group didnt use large doses, just the maximum recommended otc daily doses. in particular Ibuprofen they gave a 400mg dose at 8am, trained, tehn repeated the doses so they took 1.2g/day obviously with the 4th dose at the next 8am.[b said:
Nothing huge by any sense, adn they seem to be the main group who ahve looked at it in any real depth (same study spawned several papers)
Hmm. This is the only work I have really ever seen. Without reading the study the abstract reads like they gave full OTC dosages post-training.[b said:
Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.
Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ.
Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA. trappetodda@uams.edu
We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.
The doses were given at the start of the training session.
Below is taken directly from the methods section (p. E553) of the paper: T. A. TRAPPE, et al. Am J Physiol Endocrinol Metab 282: E551-E556, 2002.
Drug dose and administration.
Drugs were administered in a double-blind placebo-controlled fashion. Each drug was administered in three doses each day (8 AM, 2 PM, and 8 PM) corresponding to the maximal over-the-counter daily dose (ibuprofen: 400 mg per dose, total of 1,200 mg; acetaminophen: 1,500, 1,500, and 1,000 mg, total of 4,000 mg). The placebo group was given the same number of pills, which were indistinguishable from the drug doses. The first dose was given at the start of the eccentric exercise protocol ( 8 AM on day 7). On the day of the postexercise infusion protocol, the 8 AM dose was given at the start of the [2H5]phenylalanine infusion. The times of dosing were chosen to divide the maximal over-the-counter dose evenly over the day and as a result of the pharmacokinetic studies that had previously been completed on these drugs (2, 11, 19). When single doses at or near those used in the current study are consumed, ibuprofen and acetaminophen have similar pharmacokinetic parameters. Both drugs appear in the plasma within 10 min; peak levels in plasma occur within 0.5–2.0 h; and the half-life of both drugs is 2 h (2, 11, 19). The subjects were asked not to consume any other prescription or nonprescription drug during the study.
Below is taken directly from the methods section (p. E553) of the paper: T. A. TRAPPE, et al. Am J Physiol Endocrinol Metab 282: E551-E556, 2002.
Drug dose and administration.
Drugs were administered in a double-blind placebo-controlled fashion. Each drug was administered in three doses each day (8 AM, 2 PM, and 8 PM) corresponding to the maximal over-the-counter daily dose (ibuprofen: 400 mg per dose, total of 1,200 mg; acetaminophen: 1,500, 1,500, and 1,000 mg, total of 4,000 mg). The placebo group was given the same number of pills, which were indistinguishable from the drug doses. The first dose was given at the start of the eccentric exercise protocol ( 8 AM on day 7). On the day of the postexercise infusion protocol, the 8 AM dose was given at the start of the [2H5]phenylalanine infusion. The times of dosing were chosen to divide the maximal over-the-counter dose evenly over the day and as a result of the pharmacokinetic studies that had previously been completed on these drugs (2, 11, 19). When single doses at or near those used in the current study are consumed, ibuprofen and acetaminophen have similar pharmacokinetic parameters. Both drugs appear in the plasma within 10 min; peak levels in plasma occur within 0.5–2.0 h; and the half-life of both drugs is 2 h (2, 11, 19). The subjects were asked not to consume any other prescription or nonprescription drug during the study.
