Given that HSN (Prime+ & Drive+) contained antioxidants, does that mean you (Bryan) didn't use these products (on training days)?Antioxidants significantly reduced erk1/2 and had no effect on p38...I personally have stopped the high-dose antioxidants. It’s true that antioxidants have been shown to decrease the signal for hypertrophy. Will taking an antioxidant after training have a "significant" detrimental effect? I don't know. I'm the type that avoids anything that has been shown to reduce hypertrophy so I only take antioxidants during SD or on the second day of rest (weekend).