Bryan, regarding fish oil

Janne

New Member
Studies have shown that when inhibiting PGF2a elevations following exercise with NSAIDs, increases in protein synthesis are blocked as well. Since diets high in omega-3 decrease PGF2a production, does supplementing with fish oil also negatively affect protein synthesis?
 
That's a good question. One that I have considered my self many times. My opinion is that Omega-3s in reasonable doses don't interfear with growth from training. Here is my reasoning.

1) Omega-3s don't inhibit PG production like NSAIDs do.
2) Omega-3s have been found to favorably effect both insulin sensitivity as well as inhibit protein breakdown. (Sohal PS, Baracos VE, Clandinin MT. Dietary omega 3 fatty acid alters prostaglandin synthesis, glucose transport and protein turnover in skeletal muscle of healthy and diabetic rats. Biochem J. 1992 Sep 1;286 ( Pt 2):405-11.)

Finally it is important to keep in mind that too much Omega-3s is not good. It's not natural either. The beneficial effects on insulin sensitivity and inflammation can be acheived with intakes of 2 grams per day. This is considerably lower than what is used in animal studies looking at the effects on PG production.
 
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