The gum chewed periodically throughout the day will reduce your appetite and:
Nicotine appears to have a direct effect on energy expenditure and
lipolysis, and it has been shown in murine studies to shift the
expression of lipoprotein lipases away from adipose tissue and toward
muscle.[1] In that sense, it might have some added effect. However,
as to its dopaminergic appetite-suppressant effect, it is probably at
odds with bromocriptine. Nicotine causes dopamine release, while
bromocriptine binds directly to dopamine receptors (primarily D2
receptors) INSTEAD of dopamine.
Think of lipoprotein lipase (LPL for short) as a "fat partitioner", diverting fat from the diet to be stored as body fat, or burned for energy. Whether LPL promotes fat storage or fat oxidation depends on whether it's expressed in muscle or fat [4].
LPL in fat tissue takes fat from the blood, and stores it as body fat.
LPL in muscle tissue diverts fat away from storage in fat tissue and towards oxidation.
Some scientists claim that increasing LPL activity in muscle could help you lose weight permanently, suggesting that "... gene or drug delivery may prove to be an effective tool in preventing and/or treating obesity in humans". Their comments are based on research showing that mice who "overexpress" LPL in muscle appear to be resistant to the effects of a high-fat diet [7].
In short, if you want to lose weight, then more LPL in muscle tissue, and less LPL in fat tissue is definitely a "good thing".
Nicotine appears to have a direct effect on energy expenditure and
lipolysis, and it has been shown in murine studies to shift the
expression of lipoprotein lipases away from adipose tissue and toward
muscle.[1] In that sense, it might have some added effect. However,
as to its dopaminergic appetite-suppressant effect, it is probably at
odds with bromocriptine. Nicotine causes dopamine release, while
bromocriptine binds directly to dopamine receptors (primarily D2
receptors) INSTEAD of dopamine.
Think of lipoprotein lipase (LPL for short) as a "fat partitioner", diverting fat from the diet to be stored as body fat, or burned for energy. Whether LPL promotes fat storage or fat oxidation depends on whether it's expressed in muscle or fat [4].
LPL in fat tissue takes fat from the blood, and stores it as body fat.
LPL in muscle tissue diverts fat away from storage in fat tissue and towards oxidation.
Some scientists claim that increasing LPL activity in muscle could help you lose weight permanently, suggesting that "... gene or drug delivery may prove to be an effective tool in preventing and/or treating obesity in humans". Their comments are based on research showing that mice who "overexpress" LPL in muscle appear to be resistant to the effects of a high-fat diet [7].
In short, if you want to lose weight, then more LPL in muscle tissue, and less LPL in fat tissue is definitely a "good thing".
