Hitting A Muscle At Multiple Angles

Question mainly for Byran, but would like feedback from anyone that knows the actual science. Does hitting a muscle at multiple angles contribute to more growth? Specifically, does the "box car" analogy of sarcomers contracting along different sections of a muscle belly be innervated at different ranges of motion, really matter.

I am not referring to joints that have multiple planes of movement such as the shoulder, but within a single plane of movement. Example is medial deltoid. Dumbell laterals hit the top ROM. A Nautilus machine supposedly hits all the points along the range. Is the latter better? Do we have to do leg extensions because leg press and squat do not hit the top? Etc.

I know experience is valuable and should be respected, but I would like to know what the science actually says.