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I would assume that MPD always occurs as part of the remodeling process. Under the conditions described (heavy weights, adequate calories), I would guess that synthesis simply outweighs degradation. Am I close?

Ok, so, obviously I have had a lot of experience in losing muscle while trying to get lean, but I never considered that the workout alone might be responsible.  Is that what we are saying?  If my protein stays high, and my calories are at maintenance or slightly below, I might still be losing...

Gotcha. Thanks again, DKM. NWlifter, with regards to what you were saying (I never really thought of this before), does this mean that it is possible that particularly "intense" (pardon the terminology -- I don't know what else to call it) workouts while dieting might be detrimental...

Sorry, I thought that the discussion of the remodeling effect came up only in regards to the discussion of DOMS. Thus, I thought the two were always linked. My mistake. Doesn't protein synthesis mean an increase in protein structure or muscle? DKM said, the "structure change could be...

Easy now FAZ. Don't make me come out there. ;)

DKM, you're killing me.

Well, certainly increased protein synthesis is what we're after, and muscle injury, damage, or trauma seems to be associated with kicking off the cascade of events leading to growth, so ... if this is all associated with "remodeling", wouldn't that mean that DOMS is, in fact, pretty...

Thanks, DKM. Very helpful. Now the only question remaining is about remodeling. Is remodeling the same as growth, or is it just repair (and home improvement) work that doesn't necessarily lead to an increase in size?

Brak, 55% of your calories are coming from protein?!? That's over 250 grams of protein for a 2000 calorie/day diet. Wow. As far as carbs and timing and all that, ... it doesn't seem to make all that much difference, but I think that there is some info on that in the faq. For the most part, I...

So, DKM, if I'm following you, the suggestion is that actual damage may not be necessary to induce "remodeling" in a muscle. Does remodeling necessarily mean growth? Also, if it is possible for a training stimulus to proliferate satellite cells, but not cause differentiation ... umm...

Was this after a long layoff? Usually only beginners, or people who have been away from training for a long time, can lose bf and gain muscle simultaneously. Even my most productive bulk/cut cycles only yielded me a couple pounds of "permanent" weight gain. Please keep us posted as to...

JV, Yeah, I'm nowhere near where my natural limit should be. I'm also naturally lean, so my partitioning ratio should be pretty good. I've tried everything I can think of, and am at a loss. Isn't it Lyle who says, "your body hates you"? Truer words were never spoken.

Well, Brak, I feel your pain. I have been in the same position for quite some time now. I can gain weight just fine, but no matter how slowly I lose the fat, I end up right back where I started. My last cycle I gained 14 pounds and an inch and a half around my waist. By the time my waist...

I have actually tried this a few times and that is precisely the problem that I have encountered -- losing muscle. Now, I tend to have a hard time hanging onto my gains when I'm under a caloric deficit anyway, so I might not be the best person to judge this approach. However, in my experience...

I think that we can't forget that the most important element in determining the effectiveness of training is the relationship between the condition of the tissue and the relative load. As others have said, the more deconditioned you are, the better anything will work. That being said, you are...

I'm a big fan of extending sd.  If you've been training for a long time, I think its necessary, and particularly since you did so much heavy lifting last cycle (lots of 5s and negatives), you will need the extra time off if you're going to start with light loads again.   I routinely take 16-17...

Generally, I tend to agree, however at this point I'm doing heavy negatives with almost everything -- including curls and other isolation exercises. So, I'm not entirely sold that curls with 110% of my 1rm are not causing some damage. Anyway, the biggest part of my question is, I suppose, about...

I can't speak to the second question, but I have been doing uprights with a wide grip on an ez curl bar. No injuries in the two years since I started with this exercise, and it has definitely made a difference in my medial delts.

But getting inadequate amounts of EFAs won't inhibit one's ability to either lose fat or gain muscle, correct? Thanks, by the way, DKM. You've been very helpful.

I'm wondering if I am wasting my time still doing exercises with my 5rm while doing negatives with other exercises in excess of my 1rm. For instance, I'm doing chin-ups with 50 pounds strapped around my waist. But I can't do this kind of thing with 1-arm rows, so I've continued to use my 5rm...